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NFL Picks Against the Spread Week 15

With some tremendous surprises and upsets already this season, the 2022 NFL season is now in full swing. With our in-house specialists and computer models, we’ve discovered the greatest ATS picks for week 15.

Thursday Night Football

San Francisco 49ers vs. Seattle Seahawks

This is also Brock Purdy’s first road test, and with Deebo Samuel out, I’m not sure we can just chalk up another awful game from the Seattle D in this spot. The Seahawks are coming off a bad loss but have scored 24-plus in six of their last seven games, and I think they throw the kitchen sink at San Francisco in this last attempt to stay in the divisional race. 

Key Betting Line: Seahawks are 8-2-2 ATS in their last 12 Thursday games.

  • ATS: Seahawks +3.5

Sunday Football

Indianapolis Colts @ Minnesota Vikings

  • ATS: Vikings -4.5

Baltimore Ravens @ Cleveland Browns

Lamar Jackson is out of this game while DeShaun Watson will get his first start in front of the Browns nation. This is his do or die game.

  • ATS: Browns -2.5

Miami Dolphins @ Buffalo Bills

With the temperature going to. be one of the lowest this season and snow coming into play, this is a perfect Bills game to run wild over the struggling Dolphins.

Key Betting Trend: Bills are 5-1 ATS in their last 6 games in Week 15.

  • ATS: Bills -7

Detroit Lions @ New York Jets

The Detroit Lions are fighting for the last playoff spot and after taking down the Vikings, it’s clear Jared Goff is doing everything to make it happen.

  • ATS: Lions -1

Kansas City Chiefs @ Houston Texans

  • ATS: Chiefs -14

Pittsburgh Steelers @ Carolina Panthers

QB Sam Darnold has slowly turned this Panthers offense around but takes on a rough Steelers defense that might make him see ghosts again.

  • ATS: Steelers +2.5

Philadelphia Eagles @ Chicago Bears

  • ATS: Eagles -9

Atlanta Falcons @ New Orleans Saints

Desmond Rider is getting his first NFL start, but it’s on the road against a tough Saints defense. Rough.

Key Betting Trend: Saints are 4-1 ATS in their last 5 home games vs. a team with a losing road record.

  • ATS:: Saints -4.5

Dallas Cowboys @ Jacksonville Jaguars

The Dallas Cowboys are going up against a tough Jaguars team, who some may say Trevor Lawrence might out play Dak. Let’s find out.

  • ATS: Jaguars +4.5

Arizona Cardinals @ Denver Broncos

  • ATS: Broncos -3

New England Patriots @ Las Vegas Raiders

  • ATS: Raiders -1

Cincinnati Bengals @ Tampa Bay Buccaneers

  • ATS: Bengals -3.5

Tennessee Titans @ Los Angeles Chargers

Justin Herbert is a asocial media QB right? The Chargers are feeling well and will take on a one way Titans offense.

  • ATS: Chargers -3

Sunday Night Football

New York Giants @ Washington Commanders

The Giants should have beaten the Commanders in Week 13 when they tied 20-20. But this spot favors Washington, which comes off its bye and could get Chase Young back.

Key Betting Trend: Commanders are 6-1 ATS in their last 7 games after accumulating more than 150 yards rushing in their previous game.

  • ATS: Commanders -4.5

Monday Night Football

Los Angeles Rams @ Green Bay Packers

Baker Mayfield got his first win of the NFL season with the Rams but now he has to go on the road where the noise and weather is going to ruin that.

Key Betting Trend: Packers are 13-6 ATS in their last 19 games after accumulating more than 350 total yards in their previous game.

  • ATS: Packers -6.5

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