This week’s Detroit Lions vs San Francisco 49ers NFL game will be held at Levi’s Stadium, Santa Clara, California, at 3:30 pm on Sunday. You can watch the game on FOX.

Detroit Lions vs San Francisco 49ers

3:30 pmSunday, January 28, 2024Levi’s Stadium
Detroit Lions vs San Francisco 49ers Prediction

Moneyline Lions: / Moneyline 49ers:

Spread Lions: / Spread 49ers:


Lions vs 49ers Prediction

This week’s Detroit Lions vs San Francisco 49ers prediction has the Lions roaring their way to Levi’s Stadium in Santa Clara, California, to take on the 49ers at home.

The last time the Lions and 49ers met on September 12, 2023, the 49ers beat the Lions 41-33 in one of the best games of the season.

You couldn’t ask for much more in a finals game with the Lions and 49ers being two of the very best teams in the league right now, the 49ers however do have an edge over the Lions in both defense and offense, the Lions on the other hand have lead in passing which will prove to be a challenge for the 49ers

In their last game the 49ers beat the Packers 24-21, while the Lions beat the Buccaneers 31-23 in expected wins for both teams.

Betting Pick: 49ers

Who do you think will win this week’s Lions/49ers against the spread?

Lions vs 49ers Injury Report

Team Stats

Total Yards6917696649
Passing Yards4401438417
Rushing Yards2311238978
Average Yards per Play671
Points Scored46149130
Fumbles Lost1165
Interceptions Thrown12120
Sacks Allowed31343
3rd Down Efficiency41%47%6%
Time of Possession Per Game28:5328:520:01
Total Yards Allowed60715474597
Passing Yards Allowed42053642563
Rushing Yards Allowed1509152516
Points Allowed39529897
Fumbles Recovered660
Allowed 3rd Down Efficiency37%40%3%

General Assessment of Teams’ Performance

The matchup between the Detroit Lions and the San Francisco 49ers presents a closely contested game, with both teams exhibiting strengths in different areas. The statistics indicate a slight edge for the 49ers in total yards and points scored, while the Lions have an advantage in passing yards and time of possession.

Offensive Analysis

  • Total Yards: The 49ers (6,966) slightly outgain the Lions (6,917), indicating a balanced and efficient offensive approach.
  • Passing/Rushing Yards: The Lions lead in passing yards (4,401 to 4,384), while the 49ers have a better rushing game (2,389 to 2,311). This suggests the Lions favor an air attack, whereas the 49ers lean more towards the ground game.
  • Points Scored: The 49ers scoring 30 more points over the season demonstrate a slightly more effective scoring offense.
  • 3rd Down Efficiency: The 49ers’ superior efficiency (47% to 41%) indicates better execution in crucial downs.

Defensive Analysis

  • Total Yards Allowed: The Lions have allowed more total yards (6,071 to 5,474), particularly in the passing game, suggesting a weaker defense against aerial attacks.
  • Points Allowed: The 49ers have a significantly more vigorous defense, conceding 97 fewer points.
  • Sacks and Interceptions: The 49ers also lead in sacks (48 to 41) and interceptions (22 to 16), highlighting a more aggressive and effective defensive unit.

Special Teams and Discipline

  • Fumbles and Recoveries: Both teams are even in terms of fumbles recovered. However, the Lions have lost more fumbles, indicating a potential vulnerability.
  • Penalties: Both teams have a similar number of penalties, with the 49ers slightly higher. This aspect has a minimal impact on the overall game.


  • Offense: The 49ers rank higher in overall offense (3rd vs. 19th), driven by their efficient rushing (3rd) and passing (4th) compared to the Lions’ 2nd and 5th rankings, respectively.
  • Defense: The 49ers also have a superior defensive ranking (8th vs. 2nd), indicating a more robust defensive unit.

Win Probability

  • Detroit Lions: 45%
  • San Francisco 49ers: 55%

Detroit Lions vs San Francisco 49ers Prediction

Based on the analysis, the San Francisco 49ers hold a slight edge over the Detroit Lions. Their balanced offense and a more robust defense give them a higher win probability. The key will be their ability to maintain their rushing efficiency and capitalize on the Lions’ weaker pass defense. However, the Lions’ strong passing game could challenge the 49ers’ defense, making this a potentially close game. Expect a competitive match, with the 49ers likely to emerge victorious in a tight contest.